Instillagel FAQ

Below are some frequently asked questions (FAQ) regarding the use of Instillagel.

Q. How do I use Instillagel?
Instillagel is administered directly into your urethra (the canal leading to your bladder) with a pre-filled, sterile syringe. Your healthcare professional will instruct you on the proper process to use Instillagel. You may also refer to the instructions in the Patient Information Leaflet.

The syringe is for single use only. If the complete contents are not used, the syringe and remaining gel must be thrown away.

Do not swallow Instillagel or introduce it into your body by any other means. Avoid contact with your eyes or ears.

Q. How much Instillagel do I use?
A. Instillagel comes in pre-filled, easy-to-use 6 mL and 11 mL syringes. Your doctor will instruct you on the quantity of Instillagel to use at home. Do not use more Instillagel than your doctor has recommended.

For adult men, the usual dose is 11 mL; for adult women, the usual dose is 6 mL. Do not use more than 4 doses during a 24-hour period. Your doctor will instruct you on the dose for your child, as this will depend on age and weight.

Instillagel has been prescribed for your current medical problem only. Do not give it to other people.

Q. What do I do if I’ve applied too much Instillagel?
A. In case of overdose, contact your healthcare professional, hospital emergency department, or regional Poison Control Centre immediately, even if there are no symptoms.
Q. Does catheterization hurt?
A. Insertion of a catheter or other medical instrument into your urethra naturally presents the potential for injury, pain and infection. Instillagel helps by lubricating the urethra, allowing for smoother insertion of the catheter. The anaesthetic and antiseptic components of Instillagel (lidocaine and chlorhexidine, respectively) reduce pain and the risk of microbial infection following urological interventions.

After the procedure, you may experience some soreness when the anaesthetic effect has worn off.

Q. How should I store Instillagel?
A. If you are using Instillagel for self-catheterization, store the unopened blister packs below 25°C. Syringes are for single-use only. Discard any syringes with remaining gel. Do not use after the expiry date shown on the package.

Keep Instillagel out of the reach of children.

Q. What does Instillagel contain?
A. The medicinal ingredients in Instillagel are lidocaine hydrochloride (2% w/w) and chlorhexidine gluconate (0.05% w/w).

The non-medicinal ingredients are: methylparaben, propylparaben, hydroxyethylcellulose, sodium hydroxide, propylene glycol and purified water.

Q. Who can I contact if I have questions?
A. Do not hesitate to ask your healthcare professional if you have questions about Instillagel, catheterization, cystoscopy, or other related topics.

Patient Information Leaflet

Click here for the Instillagel Information leaflet designed specifically for patients. This leaflet is a summary and will not tell you everything about Instillagel. Contact your doctor or pharmacist if you have any questions about Instillagel.

For questions on Instillagel, you may also contact the Medical Information department at 1-888-550-6060 or medinfo@pendopharm.com.

Warnings and Precautions

Instillagel is for topical use only and is not to be injected.

Before using Instillagel, tell your doctor if:

  • you have ever had an unusual or allergic reaction to any of the ingredients in Instillagel, to another lidocaine or other medicine ending in “caine”, or to chlorhexidine or chlorhexidine-containing medicines or chlorhexidine-coated catheters. (For the complete list of ingredients in Instillagel, see the FAQ “What does Instillagel contain?”)
  • there is an infection, cut or rash at or near the area where you will apply Instillagel
  • you have heart, liver or kidney problems, or malignant hyperthermia (a hereditary condition)
  • you are pregnant or breastfeeding
  • you are epileptic or in severe shock

It is also important to tell your doctor if you are taking any other medications (prescription or non-prescription). Examples of drugs that may interact with Instillagel include some other local anaesthetics, heart medications, antibiotics, and mental health medications.

Side Effects

Instillagel has been studied since the early 1970s, and is known to be very well tolerated by patients.

Like with all medicines, however, patients may experience side effects. You might feel a slight stinging after the gel is used, but this stops as soon as the local anaesthetic starts to work (within 5 to 10 minutes of Instillagel being applied).

Most people find that there are no problems after Instillagel has been used, but there may be some soreness when the effect of the local anaesthetic lidocaine has worn off.

Serious side effects are rare. Should any of the following occur, stop using Instillagel right away and seek immediate medical attention:

Rare serious side effects:

  • Allergic reaction such as shortness of breath, feeling faint, chest pain, and/or faster than usual heartbeat, not present before using Instillagel

Very rare serious side effects:

  • Overdose, whose signs include drowsiness, numbness of your tongue, light-headedness, ringing in your ears, blurred vision, vomiting, dizziness, unusually slow heartbeat, fainting, nervousness, unusual sweating, trembling and/or seizures

Other side effects not listed above may also occur in some patients. If you notice any other effects or if you feel that you have had any reaction to Instillagel, tell your doctor immediately.

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